Scientific Articles

List of Scientific Articles of Allaсhem’s Scientists

  1. Morozova M.A., Lepikina T. A., Rupchev G. E., Beniashvily A. G., Burminskiy D. S., Potanin S. S., Bondsrenko E. V., Kazey V. I., Lavrovsky Y., Ivachtchenko A.V. Add-on clinical effects
    of selective antagonist of 5HT6 receptors AVN-211 (CD-008-0173) in patients with
    schizophrenia stabilized on antipsychotic treatment: pilot study. CNS Spectrums, FirstView Article, 1-8 (2013). http://journals.cambridge.org/abstract_S1092852913000394.
  2. Ivachtchenko, A. V.; Golovina, E. S.; Kadieva, M. G.; Mitkin, O. D.; Tkachenke S.E.; Okun, I.M. Synthesis of Substituted Diphenyl Sulfones and Their Structure-Activity Relationship with the Antagonism of 5-НТ6 Receptors. Bioorg. Med. Chem., 21б 4614-4627 (2013).
  3. Ivachtchenko, A. V.; Golovina, E. S.; Kadieva, M. G.; Kysil, V. M.; Mitkin, O. D.; Vorobiov, A. A.; Okun, I. M. Antagonists of 5-HT6 receptors. Substituted 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[4,3-d]pyrimidines — synthesis and «structure – activity» relationship. Bioorg. Med. Chem. Lett., 22, 4273-4280 (2012).
  4. Ivachtchenko, A. V.; Golovina, E. S.; Kadieva, M. G.; Kysil, V. M.; Mitkin, O. D.; Tkachenko, S. E.; Okun, I. M. Synthesis and SAR of 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines as potent serotonin 5-HT6 receptor antagonists. Bioorg. Med. Chem. 19, 1482–1491(2011).
  5. Ivachtchenko, A. V.; Golovina, E. S.; Kadieva, M. G.; Koryakova, A. G.; Mitkin, O. D.; Tkachenko, S. E.; Kysil, V. M.; Okun, I. M. 2-Substituted 5,6-dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines: New series of highly potent and specific serotonin 5-HT6 receptor antagonists. Eur. J. Med. Chem., 46 1189-1197(2011).
  6. Ivachtchenko, A. V.; Golovina, E. S.; Kadieva, M. G.; Kysil, V. M.; Mitkin, O. D.; Tkachenko, S. E.; Okun, I. M. Synthesis and Structure Activity Relationship (SAR) of (5,7-disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as Potent Serotonin 5-HT6 Receptor (5-HT6R) Antagonists. J. Med. Chem., 54, 8161-8173 (2011).
  7. Ivachtchenko, A. V.; Frolov, E. B.; Mitkin, O. D.; Tkachenko, S. E.; Okun, I. M.; Khvat, A. V. Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles. Bioorg. Med. Chem. Lett., 20(1), 78–82 (2010).
  8. Ivachtchenko, A. V.; Dmitriev, D. E.; Golovina, E. S.; Dubrovskaya, E. S.; Kadieva, M. G.; Koryakova, A. G.; Kysil, V. M.; Mitkin, O. D.; Tkachenko, S. E.; Okun, I. M.; Vorobiov, A. A. Synthesis of cycloalkane-annelated 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines and their evaluation as 5-HT6 receptor antagonists. Bioorg. Med. Chem. Lett., 20(7), 2133–2136 (2010).
  9. Tsirulnikov, S.; Kysil, V.; Ivachtchenko, A.; Krasavin, M. Trimethylsilyl Chloride as a Promoter for the Groebke-Blackburn Reaction: Preparation of Imidazo[2,1-b][1,3]Benzothiazoles. Synth. Comm., 40(1), 111–119 (2010).
  10. Ivachtchenko, A. V.; Mitkin, O. D.; Tkachenko, S. E.; Okun, I. M.; Kysil, V. M. 8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists. Eur. J. Med. Chem., 45(2), 782–789 (2010).
  11. Ivachtchenko, A. V.; Golovina, E. S.; Kadieva, M. G.; Koryakova, A. G.; Kovalenko, S. M.; Mitkin, O. D.; Okun, I. M.; Ravnyeyko, I. M.; Tkachenko S. E.; Zaremba, O. V. Synthesis and biological study of 3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines as potent and selective serotonin 5-HT6 receptor antagonists. Bioorg. Med. Chem., 18, 5282–5290 (2010).
  12. Ivachtchenko, A. V.; Golovina, E. S.; Kadieva, M. G.; Koryakova, A. G.; Kysil, V. M.; Mitkin, O. D.; Okun, Ravnyeyko, I. M.; I. M.; Tkachenko, S. E.; Zaremba O. V. Solution Phase Parallel Synthesis of Substituted 3-Phenylsulfonyl-[1,2,3]triazolo[1,5-a]quinazolines: Selective Serotonin 5-HT(6) Receptor Antagonists. J. Comb. Chem., 12, 445–452 (2010).
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